|
KMID : 1145120190170010057
|
|
Asian Journal of Beauty and Cosmetology
2019 Volume.17 No. 1 p.57 ~ p.67
|
|
|
Improving the Rheological Properties of Cross-linked Hyaluronic Acid Gels by Mixing in Mannitol as a Radical Scavenger
|
|
Kim E-Sle
Choi Bok-Ryul
Kang Ju-Hee
Lee Keyong-Ho
|
|
|
Abstract
|
|
|
Purpose: This study aimed to evaluate the effect of mixing mannitol into crosslinked hyaluronic acid gels on their rheological properties.
Method: Cross-linked hyaluronic acid gels were prepared by mixing in mannitol to our own manufacturing process, and then the changes in their rheological properties due to chemical and thermal oxidative stress were investigated. The rheological factors evaluated were the storage modulus (G'), loss modulus (G"), complex viscosity (G*) and phase angle (P/A).
Results: Mixing mannitol into the cross-linked hyaluronic acid gels caused their elasticity (G') and viscosity (G") to resist both frequency increase and oxidative stress caused by chemical and thermal stress. Adding mannitol also resulted in improved urine secretion in an animal model, and we therefore expect that it will reduce edema due to osmotic pressure.
Conclusion: Mannitol’s antioxidant effect contributed to the improving the cross-linked hyaluronic acid gels’ rheological properties.
|
|
|
KEYWORD
|
|
|
Hyaluronic acid, Mannitol, Cross-linked gel, Rheology, Oxidative stress
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|